UCSF Adult Restricted Antimicrobials

sort ascending
Voriconazole

Restricted to ID or Antimicrobial Stewardship except:

1) Prophylaxis against fungal infections on the hematology/BMT/lung/heart transplant services​

2) Suspected or documented serious fungal infection in the hematology/BMT/lung transplant services​

3) Empiric therapy for prolonged febrile neutropenia in hematology/oncology/BMT patient

Tigecycline

Restricted to ID or Antimicrobial Stewardship 

Tedizolid

Restricted to ID or Antimicrobial Stewardship 

ZSFG: Non-formulary

Sulbactam/durlobactam

Restricted to ID or Antimicrobial Stewardship approval for CR-ABC infections

ZSFG: Non-formulary

Posaconazole

IV formulation - Restriced to ID or Antimicrobial Stewardship except:

Inability to tolerate or absorb enteral medications and one of the following:​

1) Prophylaxis against fungal infections in patients on the hematology/BMT/lung/heart transplant services with an intolerance of or contraindications to voriconazole

2) Suspected or documented serious fungal infection in the hematology/BMT or lung transplant services

3) Empiric therapy for prolonged febrile neutropenia in hematology/oncology/BMT patient

 

PO formulation - Restricted to ID or Antimicrobial Stewardship except:

1) Prophylaxis against fungal infections in patients on the hematology/BMT/lung/heart transplant services with an intolerance of or contraindications to voriconazole

2) Suspected or documented serious fungal infection in the hematology/BMT or lung transplant services

3) Empiric therapy for prolonged febrile neutropenia in hematology/oncology/BMT patient

Polymyxin B

Restricted to ID or Antimicrobial Stewardship 

ZSFG: Non-formulary

Plazomicin

Restricted to ID or Antimicrobial Stewardship 

ZSFG: Non-formulary

Peramivir

Restricted to ID or Antimicrobial Stewardship 

ZSFG: Non-formulary

Pentamidine IV

Restricted to ID or Antimicrobial Stewardship 

Oritavancin

Restricted to ID or Antimicrobial Stewardship 

ZSFG: Non-formulary

Omadacycline

Oral formulation 

Restricted to ID or Antimicrobial Stewardship except:

1) Continuation of prior therapy

ZSFG: Non-formulary

Nirmatrelvir/ritonavir (Paxlovid)

Restricted to ASP or ID consult service (with exceptions):

- Inpatients (or those in the ED pending admission) with mild-moderate COVID-19 with symptom onset within 5 days and high-risk for progression who are admitted for reasons other than COVID-19 (see CDC Website for high-risk criteria)

Miltefosine

Restricted to ID or Antimicrobial Stewardship with exceptions:

1) Continuation of therapy 

ZSFG: Non-formulary

Micafungin

Restricted to ID or Antimicrobial Stewardship except:

1) Documented sterile site (not urine or respiratory) infection  with microbiologically confirmed Candida spp (ID/ASP approval required for durations exceeding 48h)

2) Documented sterile site infection (not urine or respiratory) infection with yeast, pending species identification (ID/ASP approval required for durations exceeding 48h)​

3) Prophylaxis against fungal infections in patients on the hematology/oncology/BMT service with intolerance of or contraindications to azoles

4) Empiric therapy for prolonged febrile neutropenia in hematology/oncology/BMT patient

Meropenem/vaborbactam

Restricted to ID or Antimicrobial Stewardship

Maribavir

Restricted to ID or Antimicrobial Stewardship except:

1) Continuation of prior therapy

ZSFG: Non-formulary

Letermovir

Restricted to ID or Antimicrobial Stewardship except:

1)  Adult malignant hematology service - for prophylaxis only per service guidelines
2)  Prophylaxis of CMV disease in high-risk kidney transplant recipients
3)  Continuation of current outpatient therapy

ZSFG: Non-formulary

Isavuconazole

Restricted to ID or Antimicrobial Stewardship except:​

1) Documented or suspected serious fungal infection in a patient with prolonged QTc interval​

2) Prophylaxis against fungal infections in patients on the hematology/BMT service or lung transplant service with prolonged QTc interval or concurrent QTc prolonging medications.

Imipenem/cilastatin/relebactam

Restricted to ID or Antimicrobial Stewardship 

Imipenem/cilastatin

Restricted to ID or Antimicrobial Stewardship 

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