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Dosing Weights
Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | Dosing | Note |
|---|---|---|
| All Indications | 2.5 mg/kg IV x1, then 1.5 mg/kg IV q12h | No renal dose adjustment |
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
| Indication | Dosing | Note |
|---|---|---|
| All Indications | 2.5 mg/kg IV x1, then 1.5 mg/kg IV q12h | No dose adjustment for hemodialysis |
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.
There are other more effective, less toxic alternatives for most multidrug-resistant Gram-negative infections. If a polymyxin is required, polymyxin B is preferred for intravenous treatment of systemic infections in adults. For treatment of urinary tract infections, or use via inhalation, use colistin (polymyxin E).
All use requires authorization from the Antimicrobial Stewardship Program or consulting ID fellow