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Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | eGFR >50mL/min/1.73m2 | 30-50 mL/min/1.73m2 | 15-30 mL/min/1.73m2 | <15 mL/min/1.73m2 |
|---|---|---|---|---|
|
All Indications 4 g = meropenem 2 g + vaborbactam 2 g |
4 g IV q8h over 3 hours | 2 g IV q8h over 3 hours | 2 g IV q12h over 3 hours | 1 g IV q12h over 3 hours |
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
|
Indication |
Intermittent Hemodialysis |
Continuous Hemodialysis |
|---|---|---|
|
All Indications 4 g = meropenem 2 g + vaborbactam 2 g |
1 g IV q12h (on HD days, administer one of the two doses after HD) | 2 g IV q8h |
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.
Restricted to ID or Antimicrobial Stewardship