| Condition | Major Pathogens | First Choice Therapy | Alternative Therapy | Comments |
|---|---|---|---|---|
|
Influenza See detailed Influenza Guidelines including treatment indications |
Influenza Virus |
Oseltamivir according to body weight: Preterm infants: <38 weeks corrected gestational age: 1 mg/kg/dose enterally bid 38-40 weeks corrected gestational age: 1.5 mg/kg/dose enterally bid >40 weeks corrected gestational age: same as term infant dosing Contact Pediatric ID/ASP for infants with corrected gestational age < 28 weeks Term infants 0-8 months: 3 mg/kg/dose enterally bid Infants 9-11 months: 3.5 mg/kg/dose enterally bid Children >=12 months: <=15kg: 30 mg/dose enterally bid >15-23kg: 45 mg/dose enterally bid >23-40kg: 60 mg/dose enterally bid >40kg: 75 mg/dose enterally bid Duration: 5 days for most patients* *For patients with critical illness or significant immunocompromise, longer courses may be considered based on severity of illness. Please consult ID for assistance in these cases. |
Zanamivir can be used for children age >= 7 years old for treatment or >= 5 years old for prophylaxis - consider in patients unable to tolerate PO but able to use dry powder inhaler: Zanamivir Duration: Treatment, most patients: 5 days* Prophylaxis: 7 days Consult Pediatric ID for use of Peramivir in critically ill patients unable to receive or absorb enteral medications Consult Pediatric ID for use of Baloxivir in patients early in course but with especially high risk for influenza-related complications |
Oseltamivir Dosing for Prophylaxis (most effective if initiated within 48-72 hours of exposure: Age < 3 months: not recommended Infants 3-8 months: 3 mg/kg/dose enterally daily Infants 9-11 months: 3.5 mg/kg/dose enterally daily Children >= 12 months: <=15kg: 30 mg/dose enterally daily >15-23kg: 45 mg/dose enterally daily >23-40kg: 60 mg/dose enterally daily >40kg: 75 mg/dose enterally daily Duration: 7 days |
References:
American Academy of Pediatrics, Committee on Infectious Diseases. Recommendations for prevention and control of influenza, 2020-2021. Pediatrics 2020;146:e2020024588.