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Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | CrCl > 130 mL/min | 45-130 mL/min | 30-44 mL/min | 15-29 mL/min | <15 mL/min |
|---|---|---|---|---|---|
|
All indications 2 g = sulbactam 1g + durlobactam 1g |
2 g IV q4h | 2 g IV q6h | 2 g IV q8h | 2 g IV q12h |
2g IV q24h*
|
*If new start, load with 2g IV q12h x3 doses prior to starting q24h regimen
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
|
Indication |
Intermittent Hemodialysis |
Continuous Hemodialysis |
|---|---|---|
|
All indications 2 g = sulbactam 1g + durlobactam 1g |
2g IV q12h x 3 doses, followed by 2g IV q24h* | No data |
*doses should be given after HD
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.
Restricted to ID/ASP approval for CR-ABC infections
ZSFG: Non-formulary