Imipenem/cilastatin/relebactam

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl >90 mL/min 60-90 mL/min 30-60 mL/min 15-30 mL/min

All Indications

1.25g = 500mg imipenem + 500 mg cilastatin + 250mg relebatam

1.25 g IV q6h 1 g IV q6h 750 mg IV q6h 500 mg IV q6h

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication

Intermittent Hemodialysis

Continuous Hemodialysis

All Indications

1.25g = 500mg imipenem + 500 mg cilastatin + 250mg relebatam

500 mg IV q6h No data

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.

All use requires authorization from the Antimicrobial Stewardship Program or consulting ID fellow

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