Imipenem/cilastatin/relebactam

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl >90 mL/min 60-90 mL/min 30-60 mL/min 15-30 mL/min

All Indications

1.25 g = imipenem 500 mg + cilastatin 500 mg + relebatam 250 mg

1.25 g IV q6h 1 g IV q6h 750 mg IV q6h 500 mg IV q6h

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication

Intermittent Hemodialysis

Continuous Hemodialysis

All Indications

1.25 g = imipenem 500 mg + cilastatin 500 mg + relebatam 250 mg

500 mg IV q6h No data

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.

Restricted to ID or Antimicrobial Stewardship 

References: