Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl > 60 mL/min 30-60 mL/min 15-30 mL/min < 15 mL/min
Gram-negative or Nocardia infections* 500 mg IV q6h 250 mg IV q6h 250 mg IV q8h Use alternative of consult ID pharmacy

Nontuberculous Mycobacteria**

1000 mg IV q12h 500 mg IV q12h 250 mg IV q12h Use alternative or consult ID pharmacy

*There may be situations that Adult ID/ASP may recommend extended infusion in certain clinical scenarios 

**Higher doses may be required for elevated imipenem MICs (8-16)

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis


Intermittent Hemodialysis

Continuous Hemodialysis
Gram-negative or Nocardia infections 500 mg IV q12h 1000 mg IV x1 dose, then 250 mg IV q6h
Nontuberculous mycobacterial infections 500 mg IV q12h 1000 mg IV x 1, then 250 mg IV q12h

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.

Restricted to ID or Antimicrobial Stewardship