Imipenem/cilastatin

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl >90 mL/min 60-90 mL/min 30-60 mL/min 15-30 mL/min
Gram-negative or Nocardia infections 500 mg IV q6h 400 mg IV q6h 300 mg IV q6h 200 mg IV q6h
Nontuberculous mycobacterial infections Consult ID/ID Pharmacy for dosing recommendations

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication

Intermittent Hemodialysis

Continuous Hemodialysis
Gram-negative or Nocardia infections 500 mg IV q12h 1000 mg IV x1 dose, then 250 mg IV q6h
Nontuberculous mycobacterial infections Consult ID/ID Pharmacy for dosing recommendations  

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.

All use requires authorization from the Antimicrobial Stewardship Program or consulting ID fellow

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