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Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | CrCl > 60 mL/min | 30-60 mL/min | 15-30 mL/min | < 15 mL/min |
|---|---|---|---|---|
| Gram-negative or Nocardia infections* | 500 mg IV q6h | 250 mg IV q6h | 250 mg IV q8h | Use alternative of consult ID pharmacy |
|
Nontuberculous Mycobacteria** |
1000 mg IV q12h | 500 mg IV q12h | 250 mg IV q12h | Use alternative or consult ID pharmacy |
*There may be situations that Adult ID/ASP may recommend extended infusion in certain clinical scenarios
**Higher doses may be required for elevated imipenem MICs (8-16)
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
|
Indication |
Intermittent Hemodialysis |
Continuous Hemodialysis |
|---|---|---|
| Gram-negative or Nocardia infections | 500 mg IV q12h | 1000 mg IV x1 dose, then 250 mg IV q6h |
| Nontuberculous mycobacterial infections | 500 mg IV q12h | 1000 mg IV x 1, then 250 mg IV q12h |
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.
Restricted to ID or Antimicrobial Stewardship