Isavuconazole

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication Dose Notes
All Indications 372 mg IV/PO Q8h x 6 doses (total of 48h), then 372 mg Q24h No renal dose adjustment

372mg of isavuconazonium=200mg of isavuconazole

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication Dose Notes
All Indications 372 mg IV/PO Q8h x 6 doses (48h), then 372 mg IV/PO Q24h No dose adjustment in hemodialysis

372mg of isavuconazonium=200mg of isavuconazole

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.

372mg of isavucazonium (prodrug) = 200mg of isavuconazole

Unrestricted Indications: 1) Documented or suspected fungal pneumonia in a patient with prolonged QT interval 2) Prophylaxis against fungal infections on the hematology/oncology/BMT service or lung transplant service in a patient with prolonged QT interval All other use requires authorization from the Antimicrobial Stewardship Program or consulting ID fellow

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Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication Dose Notes
All Indications 372 mg IV/PO Q8h x 6 doses (total of 48h), then 372 mg Q24h No renal dose adjustment

372mg of isavuconazonium=200mg of isavuconazole

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication Dose Notes
All Indications 372 mg IV/PO Q8h x 6 doses (48h), then 372 mg IV/PO Q24h No dose adjustment in hemodialysis

372mg of isavuconazonium=200mg of isavuconazole

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.

372mg of isavucazonium (prodrug) = 200mg of isavuconazole

Unrestricted Indications: 1) Documented or suspected fungal pneumonia in a patient with prolonged QT interval 2) Prophylaxis against fungal infections on the hematology/oncology/BMT service or lung transplant service in a patient with prolonged QT interval All other use requires authorization from the Antimicrobial Stewardship Program or consulting ID fellow

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