Omadacycline

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication Dosing Notes

All Indications

PO: must fast for at least 4 hours before and 2 hours after dose

200 mg IV x1, then 100 mg IV q24h

450 mg PO daily x2 doses, then 300 mg PO daily

No adjustment for renal dysfunction

Loading doses may not be required when used for non-tuberculous mycobacterial infections

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication Dosing Notes

All Indications

PO: must fast for at least 4 hours before and 2 hours after dose

200 mg IV x1, then 100 mg IV q24h

450 mg PO daily x2 doses, then 300 mg PO daily

No adjustment for hemodialysis

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.

Oral formulation 

Restricted to ID or Antimicrobial Stewardship except:

1) Continuation of prior therapy

ZSFG: Non-formulary

References: