Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | Dosing | Notes |
|---|---|---|
Bacterial infections
| 200 mg IV x1, then 100 mg IV q24h 450 mg PO daily x 2 doses, then 300 mg PO daily | No adjustment for renal dysfunction |
| Non-tuberculous mycobacterial infections | 100 mg IV q24h 300 mg PO daily |
PO: must fast for at least 4 hours before and 2 hours after dose
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
| Indication | Dosing | Notes |
|---|---|---|
Bacterial infections
| 200 mg IV x1, then 100 mg IV q24h 450 mg PO daily x 2 doses, then 300 mg PO daily | No adjustment for renal dysfunction |
| Non-tuberculous mycobacterial infections | 100 mg IV q24h 300 mg PO daily |
Dialysis Notes
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR.
IV formulation: restricted to ID or Antimicrobial stewardship except: Inability to tolerate enteral medications AND continuation of prior therapy
Oral formulation: restricted to ID or Antimicrobial Stewardship except: Continuation of prior therapy
ZSFG: Non-formulary