Letermovir

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl >10 mL/min <10 mL/min
All Indications

480 mg IV/PO q24h

With concomitant cyclosoprine: 240 mg IV/PO q24h

No dosing recommendations available

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication Dosing Notes
All Indications

480 mg IV/PO q24h

With concomitant cyclosoprine: 240 mg IV/PO q24h

No dosing recommendations available for hemodialysis

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.

Unrestricted Indications (provide on order entry):

1) CMV prophylaxis on heme/BMT service

All other use requires authorization from the Antimicrobial Stewardship Program or consulting ID fellow

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