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Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | Dosing | Notes |
|---|---|---|
| All Indications | 100 mg IV x1, then 50 mg IV q12h |
No adjustment for renal dysfunction Severe hepatic dysfunction: 100 mg IV x1, then 25 mg IV q12h |
*There may be certain situations that may require higher dosing (200 mg IV x 1, then 100 mg IV q 12h). Speak to ASP/ID pharmacy if needed.
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
| Indication | Dosing | Notes |
|---|---|---|
| All Indications | 100 mg IV x1, then 50 mg IV q12h |
No adjustment for hemodialysis Severe hepatic dysfunction: 100 mg IV x1, then 25 mg IV q12h |
*There may be certain situations that may require higher dosing (200 mg IV x 1, then 100 mg IV q 12h). Speak to ASP/ID pharmacy if needed.
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.
Restricted to ID or Antimicrobial Stewardship