Tigecycline

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication Dosing Notes
All Indications 100 mg IV x1, then 50 mg IV q12h

No adjustment for renal dysfunction

Severe hepatic dysfunction: 100 mg IV x1, then 25 mg IV q12h

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication Dosing Notes
All Indications 100 mg IV x1, then 50 mg IV q12h

No adjustment for hemodialysis

Severe hepatic dysfunction: 100 mg IV x1, then 25 mg IV q12h

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.

All use requires authorization from the Antimicrobial Stewardship Program or consulting ID fellow

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