Nirmatrelvir/ritonavir (Paxlovid)

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl >60 mL/min 30-60 mL/min <30 mL/min
All Indications 300/100 mg PO BID 150/100 mg PO BID Not recommended

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis


Intermittent Hemodialysis

Continuous Hemodialysis
All Indications No data No data

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.

Review medications for potenital drug interactions.