Plazomicin

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl >60 mL/min 30-60 mL/min 15-30 mL/min <15 mL/min
All Indications 15 mg/kg IV q24h 10 mg/kg IV q24h 10 mg/kg IV q48h Not studied

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication

Intermittent Hemodialysis

Continuous Hemodialysis
All Indications Data is limited for all forms of dialysis; consider alternatives or contact ID pharmacy  

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.

If Total BW >1.2 times Ideal BW, use Adjusted BW

All use requires authorization from the Antimicrobial Stewardship Program or consulting ID fellow

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