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| Revision | Operations | |
|---|---|---|
| 09-21-23 by ripal121 | current revision | |
| 09-21-23 by ripal121 | ||
| 07-20-23 by ripal121 | ||
| 07-20-23 by ripal121 | ||
| 02-17-22 by [email protected] | ||
| 07-23-21 by conan.macdougal... | ||
| 08-19-20 by [email protected] | ||
| 08-12-20 by conan.macdougal... | ||
| 08-12-20 by conan.macdougal... | ||
| 08-12-20 by conan.macdougal... | ||
| 08-12-20 by conan.macdougal... | ||
| 08-12-20 by conan.macdougal... | ||
| 08-12-20 by conan.macdougal... | ||
| 07-10-20 by [email protected] | ||
| 04-21-20 by ucsf_admin | ||
Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | Dose | Notes |
|---|---|---|
| All Indications | 372 mg IV/PO Q8h x 6 doses (total of 48h), then 372 mg Q24h | No renal dose adjustment |
372mg of isavuconazonium=200mg of isavuconazole
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
| Indication | Dose | Notes |
|---|---|---|
| All Indications | 372 mg IV/PO Q8h x 6 doses (48h), then 372 mg IV/PO Q24h | No dose adjustment in hemodialysis |
372mg of isavuconazonium=200mg of isavuconazole
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.
372mg of isavucazonium (prodrug) = 200mg of isavuconazole
Restricted to ID or Antimicrobial Stewardship except:
1) Documented or suspected fungal pneumonia in a patient with prolonged QTc interval
2) Prophylaxis against fungal infections in patients on the hematology/BMT service or lung transplant service with prolonged QTc interval or concurrent QTc prolonging medications.