Revisions for Daptomycin

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05-16-25 by ripal121current revision
05-16-25 by ripal121
05-16-25 by ripal121
05-15-25 by ripal121
05-15-25 by ripal121
05-1-25 by ripal121
04-22-25 by kaipe
02-7-25 by ripal121

ripal121 replaced Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR with Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. via Scanner Search and Replace module.

02-7-25 by ripal121

ripal121 replaced Intermittent HD with Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. via Scanner Search and Replace module.

07-20-23 by ripal121
06-13-22 by conan.macdougal...
07-26-21 by conan.macdougal...
07-23-21 by conan.macdougal...
10-16-20 by [email protected]
10-16-20 by [email protected]
10-16-20 by [email protected]
08-12-20 by conan.macdougal...
08-12-20 by conan.macdougal...
08-12-20 by conan.macdougal...
08-12-20 by conan.macdougal...
08-12-20 by conan.macdougal...
07-10-20 by [email protected]
07-7-20 by [email protected]
07-7-20 by [email protected]
04-20-20 by ucsf_admin
04-20-20 by ucsf_admin
02-12-20 by [email protected]
02-12-20 by [email protected]
02-12-20 by [email protected]

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl > 30 mL/min < 30 mL/min
All indications 8 – 10* mg/kg IV q24h 8 – 10* mg/kg IV q48h

*Doses up to 12 mg/kg may be indicated in treatment of some VRE infections - confer with ID/ID pharmacy.

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication

Intermittent Hemodialysis

Continuous Hemodialysis*
All Indications

8-10 mg/kg IV x1 now and post-HD

Alternate for patients not on stable dialysis schedule: 8-10 mg/kg IV q48h

6-8 mg/kg IV q 24h

Flow rates exceeding 2.5 L/hour may require higher dosing

Contact ID/ASP pharmacy for assistance

*These recommendations have not been evaluated for patients receiving continuous renal replacement therapy other than CVVHD (ex. CVVH). 

Dialysis Notes

Not effective in treatment of pneumonia.

Restricted to ID or Antimicrobial Stewardship

References: