Revisions for Sulbactam/durlobactam

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02-7-25 by ripal121

ripal121 replaced Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR with Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. via Scanner Search and Replace module.

current revision
02-7-25 by ripal121

ripal121 replaced Intermittent HD with Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. via Scanner Search and Replace module.
02-7-25 by conan.macdougal...

[email protected] replaced For detailed view of dialysis dosing and evidence, see <a href="https://idmp.ucsfsitebuilder.acsitefactory.com/content/ucsf-adult-antimicrobial-dosing-dialysis-reference-document">Dosing in Hemodialysis</a> document.</p> with via Scanner Search and Replace module.
11-4-24 by [email protected]
05-16-24 by tasissah
05-15-24 by tasissah
05-15-24 by tasissah
05-15-24 by tasissah
05-15-24 by tasissah
05-12-24 by tasissah
05-12-24 by tasissah

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl > 130 mL/min 45-130 mL/min 30-44 mL/min 15-29 mL/min <15 mL/min

All indications

2 g = sulbactam 1g + durlobactam 1g

 2 g IV q4h 2 g IV q6h 2 g IV q8h 2 g IV q12h

2g IV q24h*

 

*If new start, load with 2g IV q12h x3 doses prior to starting q24h regimen

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication

Intermittent Hemodialysis

 Continuous Hemodialysis

All indications

2 g = sulbactam 1g + durlobactam 1g

 2g IV q12h x 3 doses, followed by 2g IV q24h* No data

*doses should be given after HD 

Dialysis Notes

Restricted to ID/ASP approval for CR-ABC infections

ZSFG: Non-formulary

References: