Revisions for Miltefosine

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04-17-25 by ripal121current revision
02-7-25 by ripal121

ripal121 replaced Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR with Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. via Scanner Search and Replace module.

02-7-25 by ripal121

ripal121 replaced Intermittent HD with Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. via Scanner Search and Replace module.

02-7-25 by conan.macdougal...

[email protected] replaced For detailed view of dialysis dosing and evidence, see <a href="https://idmp.ucsfsitebuilder.acsitefactory.com/content/ucsf-adult-antimicrobial-dosing-dialysis-reference-document">Dosing in Hemodialysis</a> document.</p> with via Scanner Search and Replace module.

11-4-24 by [email protected]
09-1-23 by ripal121
09-1-23 by ripal121
09-1-23 by ripal121
09-1-23 by ripal121
08-31-23 by ripal121
08-31-23 by ripal121
08-31-23 by ripal121
08-31-23 by ripal121
08-31-23 by ripal121
08-31-23 by kaipe
08-31-23 by kaipe
08-31-23 by kaipe
08-31-23 by kaipe
08-31-23 by kaipe
08-31-23 by ripal121
08-31-23 by ripal121
08-31-23 by ripal121
08-31-23 by ripal121
08-31-23 by ripal121
08-31-23 by ripal121

Dosing Weights

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication Dose  Notes 
Amebic meningoencephalitis

< 45 kg:  50 mg PO twice daily with food

>= 45 kg:  50 mg PO three times daily with food 

No renal adjustment
Leishmaniasis

30-44 kg:  50 mg PO twice daily with food

>= 45 kg:  50 mg PO three times daily with food 

No renal adjustment

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication

Intermittent Hemodialysis

Continuous Hemodialysis
Amebic meningoencephalitis

< 45 kg:  50 mg PO twice daily with food

>= 45 kg:  50 mg PO three times daily with food 

(no adjustment for hemodialysis)

< 45 kg:  50 mg PO twice daily with food

>= 45 kg:  50 mg PO three times daily with food 

(no adjustment for hemodialysis)

Leishmaniasis

30-44 kg:  50 mg PO twice daily with food

>= 45 kg:  50 mg PO three times daily with food 

(no adjustment for hemodialysis)

30-44 kg:  50 mg PO twice daily with food

>= 45 kg:  50 mg PO three times daily with food 

(no adjustment for hemodialysis)

Dialysis Notes

Restricted to ID or Antimicrobial Stewardship with exceptions:

1) Continuation of therapy 

ZSFG: Non-formulary

References:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/204684s000lbl.pdf