Dosing Weights
Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | Dose | Notes |
|---|---|---|
| Amebic meningoencephalitis |
< 45 kg: 50 mg PO twice daily with food >= 45 kg: 50 mg PO three times daily with food |
No renal adjustment |
| Leishmaniasis |
30-44 kg: 50 mg PO twice daily with food >= 45 kg: 50 mg PO three times daily with food |
No renal adjustment |
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
|
Indication |
Intermittent Hemodialysis |
Continuous Hemodialysis |
|---|---|---|
| Amebic meningoencephalitis |
< 45 kg: 50 mg PO twice daily with food >= 45 kg: 50 mg PO three times daily with food (no adjustment for hemodialysis) |
< 45 kg: 50 mg PO twice daily with food >= 45 kg: 50 mg PO three times daily with food (no adjustment for hemodialysis) |
| Leishmaniasis |
30-44 kg: 50 mg PO twice daily with food >= 45 kg: 50 mg PO three times daily with food (no adjustment for hemodialysis) |
30-44 kg: 50 mg PO twice daily with food >= 45 kg: 50 mg PO three times daily with food (no adjustment for hemodialysis) |
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.
Restricted to ID or Antimicrobial Stewardship with exceptions:
1) Continuation of therapy
ZSFG: Non-formulary
References:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/204684s000lbl.pdf