Patient Population: Adult
| Diagnosis | Common Pathogens | Drug(s) of First Choice | Alternative Drug(s) | Comments | Expected Duration |
|---|---|---|---|---|---|
| Outpatient treatment of low-risk neutropenic fever |
Streptococci spp. Enteric gram-negative bacteria Pseudomonas aeruginosa Enterococci Staphylococci Viral infections Fungal infections |
PLUS Amoxicillin/clavulanic acid |
Levofloxacin |
Need to take into account how sick the patient is at presentation, underlying comorbidities, localizing signs/symptoms, and age. Risk calculators are available Patients already on levofloxacin prophylaxis should be treated with IV therapy Expected duration of neutropenia should be < 7 days Ensure patient has easy access to medical care and is able to tolerate oral therapy Excludes patients on prior oral antibacterial prophylaxis Consider supervised observation in clinic; schedule close outpatient follow-up |
Until afebrile at least 72 hours If source identified, tailor for source of infection |