Levofloxacin

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl > 50 mL/min 20-49 mL/min <20mL/min
Urinary tract infections 500mg IV/PO Q24h 500 mgx1, then 250mg IV/PO Q24h 500mg x1, then 250mg IV/PO Q48h
Other indications 750mg IV/PO Q24h 750mg IV/PO Q48h 750mg x1, then 500mg IV/PO Q48h

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication

Intermittent Hemodialysis

Continuous Hemodialysis
Standard Dosing 500mg x1, then 250mg IV/PO Q48h 750 mg IV/PO x1, then 250 mg IV/PO q24h
Pneumonia or Pseudomonas infections 750mg x1, then 500mg IV/PO Q48h 750 mg IV/PO x1, then 500 mg IV q24h

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.

Avoid co-administration of the oral formulation with divalent/trivalent cations (e.g. calcium, magnesium, zinc) - separate by at least 2 hours.

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