Primary tabs
Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | CrCl > 50 mL/min | 30 - 50 mL/min | < 30 mL/min |
|---|---|---|---|
|
400 mg IV q12h 500 mg PO BID |
400 mg IV q12h 500 mg PO BID |
400 mg IV q24h 500 mg PO daily |
|
| Pseudomonas infections, bloodstream infections, & induction therapy for Staphylococcus hardware infections +/- rifampin |
400 mg IV q8h 750 mg PO q12h |
400 mg IV q12h 500 mg PO q12h |
400 mg IV q24h 500 mg PO daily |
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
|
Indication |
Intermittent Hemodialysis |
Continuous Hemodialysis |
|---|---|---|
| All Indications | 400 mg IV qPM or 500 mg PO qPM | 400 mg IV q8h or 500 mg PO q12h |
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.