Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl > 30 mL/min 10 - 30 mL/min < 10 mL/min
All Indications 875/125 mg PO q12h 500/125 mg PO q12h 500/125 mg PO q24h

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis


Intermittent Hemodialysis

Continuous Hemodialysis
All Indications 500/125 mg PO x1 now, then qPM 500/125 mg PO q12h

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.