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Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | Dosing | Notes |
|---|---|---|
|
All Indications PO: must fast for at least 4 hours before and 2 hours after dose |
200 mg IV x1, then 100 mg IV q24h 450 mg PO daily x2 doses, then 300 mg PO daily |
No adjustment for renal dysfunction |
Loading doses may not be required when used for non-tuberculous mycobacterial infections
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
| Indication | Dosing | Notes |
|---|---|---|
|
All Indications PO: must fast for at least 4 hours before and 2 hours after dose |
200 mg IV x1, then 100 mg IV q24h 450 mg PO daily x2 doses, then 300 mg PO daily |
No adjustment for hemodialysis |
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.
Oral formulation
Restricted to ID or Antimicrobial Stewardship except:
1) Continuation of prior therapy