Revisions for Imipenem/cilastatin

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Revisions allow you to track differences between multiple versions of your content, and revert back to older versions.

Revision	Operations
02-7-25 by ripal121 ripal121 replaced Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR with Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. via Scanner Search and Replace module.	current revision
02-7-25 by ripal121 ripal121 replaced Intermittent HD with Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. via Scanner Search and Replace module.
02-7-25 by conan.macdougal... [email protected] replaced For detailed view of dialysis dosing and evidence, see <a href="https://idmp.ucsfsitebuilder.acsitefactory.com/content/ucsf-adult-antimicrobial-dosing-dialysis-reference-document">Dosing in Hemodialysis</a> document.</p> with via Scanner Search and Replace module.
10-19-23 by ripal121
10-19-23 by ripal121
10-18-23 by ripal121
07-20-23 by ripal121
08-29-22 by [email protected]
02-17-22 by [email protected]
08-13-20 by conan.macdougal...

Indication	CrCl > 60 mL/min	30-60 mL/min	15-30 mL/min	< 15 mL/min
Gram-negative or Nocardia infections*	500 mg IV q6h	250 mg IV q6h	250 mg IV q8h	Use alternative of consult ID pharmacy
Nontuberculous Mycobacteria**	1000 mg IV q12h	500 mg IV q12h	250 mg IV q12h	Use alternative or consult ID pharmacy

*There may be situations that Adult ID/ASP may recommend extended infusion in certain clinical scenarios

**Higher doses may be required for elevated imipenem MICs (8-16)

Indication	Intermittent Hemodialysis	Continuous Hemodialysis
Gram-negative or Nocardia infections	500 mg IV q12h	1000 mg IV x1 dose, then 250 mg IV q6h
Nontuberculous mycobacterial infections	500 mg IV q12h	1000 mg IV x 1, then 250 mg IV q12h

Restricted to ID or Antimicrobial Stewardship