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Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | CrCl > 30 mL/min | <30 mL/min |
|---|---|---|
| Single-dose regimen (skin/soft tissue infection) | 1500 mg IV x 1 dose | 1000 mg IV x 1 dose |
| Two-dose regimen (skin/soft tissue infection) | 1000 mg IV x 1 dose on day 1, then 500 mg IV X 1 on day 8 | 750 mg IV x 1 dose on day 1, then 375 mg IV X 1 on day 8 |
| Complicated Gram-positive infections (e.g. Native osteomyelitis)* | 1500 mg IV on days 1 & 8 | 1000 mg IV on days 1 & 8 |
|
*ID consult highly recommended for patient-specific recommendations. *For dosing in other complicated indications, contact ID or ID pharmacy. |
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Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
| Indication | Dose | Notes |
|---|---|---|
| Complicated Gram-positive infections (e.g. Native osteomyelitis)* | 1500 mg IV on days 1 & 8 | No dose adjustment necessary for hemodialysis |
|
*ID consult highly recommended for patient-specific recommendations. *For dosing in other complicated indications, contact ID or ID pharmacy. |
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Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.
Other dosing strategies used for treatment of bone/joint infections or bacteremia.
Restricted to ID or Antimicrobial Stewardship