Primary tabs
Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | CrCl >30 mL/min | <30 mL/min |
|---|---|---|
| Single-dose regimen (skin/soft tissue infection) | 1500 mg IV x1 dose | 1125 mg IV x1 dose |
| Two-dose regimen (skin/soft tissue infection) | 1000 mg IV x1 then 500 mg IV x1 7 days later | 750 mg IV x1, then 375 mg IV x1 7 days later |
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
| Indication | Dose | Notes |
|---|---|---|
| Single-dose regimen (skin/soft tissue infection) | 1500 mg IV x1 dose | No dose adjustment necessary for hemodialysis |
| Two-dose regimen (skin/soft tissue infection) | 1000 mg IV x1 then 500 mg IV x1 7 days later |
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.
Other dosing strategies used for treatment of bone/joint infections or bacteremia.
All use requires authorization from the Antimicrobial Stewardship Program or consulting ID fellow