Dalbavancin

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl >30 mL/min <30 mL/min
Single-dose regimen (skin/soft tissue infection) 1500 mg IV x1 dose 1125 mg IV x1 dose
Two-dose regimen (skin/soft tissue infection) 1000 mg IV x1 then 500 mg IV x1 7 days later 750 mg IV x1, then 375 mg IV x1 7 days later

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication Dose Notes
Single-dose regimen (skin/soft tissue infection) 1500 mg IV x1 dose No dose adjustment necessary for hemodialysis
Two-dose regimen (skin/soft tissue infection) 1000 mg IV x1 then 500 mg IV x1 7 days later

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.

Other dosing strategies used for treatment of bone/joint infections or bacteremia.

All use requires authorization from the Antimicrobial Stewardship Program or consulting ID fellow

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