Dalbavancin

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl 30 mL/min <30 mL/min
Single-dose regimen (skin/soft tissue infection) 1500 mg IV x 1 dose 1000 mg IV x 1 dose
Two-dose regimen (skin/soft tissue infection) 1000 mg IV x 1 dose on day 1, then 500 mg IV X 1 on day 8 750 mg IV x 1 dose on day 1, then 375 mg IV X 1 on day 8
Complicated Gram-positive infections (e.g. Native osteomyelitis)* 1500 mg IV on days 1 & 8 1000 mg IV on days 1 & 8

*ID consult highly recommended for patient-specific recommendations.​

*For dosing in other complicated indications, contact ID or ID pharmacy.

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication Dose Notes
Complicated Gram-positive infections (e.g. Native osteomyelitis)* 1500 mg IV on days 1 & 8 No dose adjustment necessary for hemodialysis

*ID consult highly recommended for patient-specific recommendations.​

*For dosing in other complicated indications, contact ID or ID pharmacy.

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.

Other dosing strategies used for treatment of bone/joint infections or bacteremia.

Restricted to ID or Antimicrobial Stewardship

References: