Revisions for Cefiderocol

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RevisionOperations
02-7-25 by ripal121

ripal121 replaced Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR with Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. via Scanner Search and Replace module.

current revision
02-7-25 by ripal121

ripal121 replaced Intermittent HD with Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. via Scanner Search and Replace module.

02-7-25 by conan.macdougal...

conan.macdougall@ucsf.edu replaced For detailed view of dialysis dosing and evidence, see <a href="https://idmp.ucsfsitebuilder.acsitefactory.com/content/ucsf-adult-antimicrobial-dosing-dialysis-reference-document">Dosing in Hemodialysis</a> document.</p> with via Scanner Search and Replace module.

10-23-24 by ripal121
05-1-24 by kaipe
09-20-23 by Annie Kim
09-13-23 by ripal121
07-20-23 by ripal121
07-26-21 by conan.macdougal...
09-29-20 by conan.macdougal...

Updated CRRT dosing recommendations based on new manufacturer data.

08-12-20 by conan.macdougal...

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl >120 mL/min 60-119 mL/min 30-59 mL/min 15-29 mL/min <15 mL/min
All Indications 2 g IV q6h infused over 3 hours 2 g IV q8h infused over 3 hours 1.5 g IV q8h infused over 3 hours 1 g IV q8h infused over 3 hours 750 mg IV q12h infused over 3 hours

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication

Intermittent Hemodialysis

Continuous Hemodialysis
All Indications 750 mg IV q12h over 3 hours

*Effluent flow rate 2 L/hr or less: 1.5 g IV every 12 hours over 3 hours

*Effluent flow rate 2.1 - 3 L/hr: 2 g IV every 12 hours over 3 hours

*Effluent flow rate 3.1 - 4 L/hr: 1.5 g IV every 8 hours over 3 hours

*Effluent flow rate > 4 L/hr: 2 g IV every 8 hours over 3 hours

Dialysis Notes

Restricted to ID or Antimicrobial Stewardship

References: