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Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | CrCl >120 mL/min | 60-119 mL/min | 30-59 mL/min | 15-29 mL/min | <15 mL/min |
|---|---|---|---|---|---|
| All Indications | 2 g IV q6h infused over 3 hours | 2 g IV q8h infused over 3 hours | 1.5 g IV q8h infused over 3 hours | 1 g IV q8h infused over 3 hours | 750 mg IV q12h infused over 3 hours |
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
|
Indication |
Intermittent Hemodialysis |
Continuous Hemodialysis |
|---|---|---|
| All Indications | 750 mg IV q12h over 3 hours |
*Effluent flow rate 2 L/hr or less: 1.5 g IV every 12 hours over 3 hours *Effluent flow rate 2.1 - 3 L/hr: 2 g IV every 12 hours over 3 hours *Effluent flow rate 3.1 - 4 L/hr: 1.5 g IV every 8 hours over 3 hours *Effluent flow rate > 4 L/hr: 2 g IV every 8 hours over 3 hours |
Dialysis Notes
*Effluent rate (per prescribing information): Ultrafiltrate flow rate for CVVH, dialysis flow rate for CVVHD, ultrafiltrate flow rate plus dialysis flow rate for CVVHDF
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.
Restricted to ID or Antimicrobial Stewardship