Cefiderocol

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl >120 mL/min 60-119 mL/min 30-59 mL/min 15-29 mL/min <15 mL/min
All Indications 2 g IV q6h infused over 3 hours 2 g IV q8h infused over 3 hours 1.5 g IV q8h infused over 3 hours 1 g IV q8h infused over 3 hours 750 mg IV q12h infused over 3 hourse

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication

Intermittent Hemodialysis

Continuous Hemodialysis
All Indications 750 mg IV q12h over 3 hours

Effluent flow rate 2 L/hr or less: 1.5 g IV every 12 hours over 3 hours

Effluent flow rate 2.1 - 3 L/hr: 2 g IV every 12 hours over 3 hours

Effluent flow rate 3.1 - 4 L/hr: 1.5 g IV every 8 hours over 3 hours

Effluent flow rate > 4 L/hr: 2 g IV every 8 hours over 3 hours

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.

All use requires authorization from the Antimicrobial Stewardship Program or consulting ID fellow

0