Community Acquired Sepsis

Diagnosis Common Pathogens Drug(s) of First Choice Alternative Drug(s) Comments Expected Duration
Community Acquired Sepsis

Enterobacteriaceae

S. aureus

Streptococci spp.

Vancomycin

PLUS one of:

Ceftriaxone

OR

Piperacillin/tazobactam

OR

Ertapenem

For severe beta-lactam allergy:

Vancomycin

PLUS

Metronidazole

PLUS

Aztreonam

 

Stop antibiotics at 48 hours if work-up does not reveal a source of infection

Duration should otherwise be tailored to clinical or microbiological source