Metronidazole

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl >10 mL/min CrCl < 10 mL/min
Standard Dose  500 mg IV/PO Q8h 500 mg IV/PO Q12h
Bacterial vaginosis  500 mg IV/PO Q12h 500 mg IV/PO Q12h

Intra-abdominal infections (excluding C. difficile)

500 mg IV/PO Q12h 500 mg IV/PO Q12h
Vaginal Trichomoniasis  500 mg IV/PO Q12h 500 mg IV/PO Q12h

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication

Intermittent Hemodialysis

Continuous Hemodialysis
Standard Dose 500 mg IV/PO Q8h 500 mg IV/PO Q8h
Bacterial vaginosis 500 mg IV/PO Q12h 500 mg IV/PO Q12h
Intra-abdominal infections (excluding C. difficile) 500 mg IV/PO Q12h 500 mg IV/PO Q12h
Vaginal Trichomoniasis 500 mg IV/PO Q12h 500 mg IV/PO Q12h

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.

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