Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl > 30 mL/min < 30 mL/min
All indications 1 g IV q24h 500 mg IV q24h

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis


Intermittent Hemodialysis

Continuous Hemodialysis
All Indications

500 mg IV x1 now then qPM

Alternate: 500 mg - 1 g IV x1 now, then post-HD*

1 g IV q24h

*Post-HD dosing strategy should be used on a case-by-case basis after careful consideration of the benefits of post-HD only dosing and risks of ertapenem toxicity. Consider 500 mg dose in advanced age and low body weight (< 40 kg). Consult ID pharmacy for guidance.

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.