Ceftriaxone

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication Dose Notes
Standard Dose 1 g IV q24h No renal dose adjustment
Serious Infections, Non-enterococcal Endocarditis, Osteomyelitis, Septic Arthritis 2 g IV q24h  No renal dose adjustment

Meningitis & Enteroccocal Endocarditis (in combination with ampicillin)

2 g IV q12h No renal dose adjustment

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication Dose Notes
Usual dose 1 g IV q24h

 

No dose adjustment for hemodialysis

Endocarditis & Osteomyelitis 2 g IV q24h 

Meningitis & Enteroccocal Endocarditis (in combination with ampicillin)

2 g IV q12h

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.