Revisions for Ampicillin/sulbactam (Unasyn)

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10-26-23 by ripal121current revision
10-26-23 by ripal121
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10-26-23 by ripal121
10-26-23 by ripal121
10-19-23 by tasissah

Adult ID/ASP may recommend 9 g IV q 8h (with extended infusion over 4 hours) in certain cases

10-19-23 by tasissah
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09-25-23 by ripal121
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04-17-20 by ucsf_admin
04-17-20 by ucsf_admin

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl > 30 mL/min

15 – 30 mL/min

< 15 mL/min

All indications 3 g IV q6h 3 g IV q12h 3 g IV q24h

Carbapenem-resistant 

Acinetobacter baumannii

3 g IV q4h 3 g IV q8h

3 g IV q12h

 

Extended Infusion Dosing (if recommended by ID or ID pharmacy)

Indication CrCl > 60 mL/min

30-59 mL/min

<30mL/min

Carbapenem-resistant Acinetobacter baumannii

9 gram IV q 8h (over 4 hours)

6 grams IV q 8h (over 4 hours)​

Short infusion 

(follow the dosing recs of 3 g IV q 4h schematic) 

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication

Intermittent Hemodialysis

Continuous Hemodialysis
All Indications 3g IV q12h 3g IV q6h

Carbapenem-resistant 

Acinetobacter baumannii

3g IV q12h 3g IV 4h

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.

References: