Primary tabs
Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | CrCl > 30 mL/min |
15 – 30 mL/min |
< 15 mL/min |
|---|---|---|---|
| All indications | 3 g IV q6h | 3 g IV q12h | 3 g IV q24h |
|
Carbapenem-resistant Acinetobacter baumannii |
3 g IV q4h | 3 g IV q8h |
3 g IV q12h
|
Extended Infusion Dosing (if recommended by ID or ID pharmacy)
| Indication | CrCl > 60 mL/min |
30-59 mL/min |
<30mL/min |
|---|---|---|---|
|
Carbapenem-resistant Acinetobacter baumannii |
9 gram IV q 8h (over 4 hours) |
6 grams IV q 8h (over 4 hours) |
Short infusion (follow the dosing recs of 3 g IV q 4h schematic) |
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
|
Indication |
Intermittent Hemodialysis |
Continuous Hemodialysis |
|---|---|---|
| All Indications | 3g IV q12h | 3g IV q6h |
|
Carbapenem-resistant Acinetobacter baumannii |
3g IV q12h | 3g IV 4h |
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.