Revisions for Ganciclovir

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01-11-24 by kaipecurrent revision
07-26-21 by conan.macdougal...
07-23-21 by conan.macdougal...
09-6-20 by conan.macdougal...
08-31-20 by conan.macdougal...
08-31-20 by conan.macdougal...

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl >70 mL/min 50-69 mL/min 25-49 mL/min 10-24 mL/min
CMV Treatment 5 mg/kg IV q12h 2.5 mg/kg IV q12h 2.5 mg/kg IV q24h 1.25 mg/kg IV q24h
CMV Prophylaxis 2.5 mg/kg IV q12h 2.5 mg/kg IV q24h 1.25 mg/kg IV q24h 0.625 mg/kg IV q24h

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication

Intermittent Hemodialysis

Continuous Hemodialysis
CMV Treatment 1.25 mg/kg IV x1 now and post-HD 2.5 mg/kg IV q12h*
CMV Prophylaxis 0.625 mg/kg IV x1 now and post-HD 2.5 mg/kg IV q24h

*Higher or more frequent doses may be warranted for higher CVVHD flow rates. Lower frequency may be indicated for lower CVVHD flow rates.

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.

References: