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Dosing Weights
Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | CrCl >70 mL/min | 50-69 mL/min | 25-49 mL/min | 10-24 mL/min |
|---|---|---|---|---|
| CMV Treatment | 5 mg/kg IV q12h | 2.5 mg/kg IV q12h | 2.5 mg/kg IV q24h | 1.25 mg/kg IV q24h |
| CMV Prophylaxis | 2.5 mg/kg IV q12h | 2.5 mg/kg IV q24h | 1.25 mg/kg IV q24h | 0.625 mg/kg IV q24h |
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
|
Indication |
Intermittent Hemodialysis |
Continuous Hemodialysis |
|---|---|---|
| CMV Treatment | 1.25 mg/kg IV x1 now and post-HD | 2.5 mg/kg IV q12h* |
| CMV Prophylaxis | 0.625 mg/kg IV x1 now and post-HD | 2.5 mg/kg IV q24h |
*Higher or more frequent doses may be warranted for higher CVVHD flow rates. Lower frequency may be indicated for lower CVVHD flow rates.
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.