Ganciclovir

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl >70 mL/min 50-69 mL/min 25-49 mL/min 10-24 mL/min
CMV Treatment 5 mg/kg IV q12h 2.5 mg/kg IV q12h 2.5 mg/kg IV q24h 1.25 mg/kg IV q24h
CMV Prophylaxis 5 mg/kg IV q24h 2.5 mg/kg IV q24h 1.25 mg/kg IV q24h 0.625 mg/kg IV q24h

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis

Indication

Intermittent Hemodialysis

Continuous Hemodialysis
CMV Treatment 1.25 mg/kg IV x1 now and post-HD 2.5 mg/kg IV q12h*
CMV Prophylaxis 0.625 mg/kg IV x1 now and post-HD 2.5 mg/kg IV q24h

*Higher or more frequent doses may be warranted for higher CVVHD flow rates. Lower frequency may be indicated for lower CVVHD flow rates.

Dialysis Notes

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR.

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