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Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | CrCl >50 mL/min | 30-50 mL/min | 15-29 mL/min |
|---|---|---|---|
| Complicated urinary tract infection | 1.5 g IV q8h (infused over 3 hours) | 750 mg IV q8h (infused over 3 hours) | 375 mg IV q8h (infused over 3 hours) |
| Pneumonia, severe infections | 3 g IV q8h (infused over 3 hours) | 1.5 g IV q8h (infused over 3 hours) | 750 mg IV q8h (infused over 3 hours) |
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
|
Indication |
Intermittent Hemodialysis |
Continuous Hemodialysis |
|---|---|---|
| Complicated urinary tract infection | 750 mg IV x1 (infused over 3 hours), then 150 mg IV q8h (infused over 3 hours) | No data |
| Pneumonia, severe infections | 2.25 g IV x1 (infused over 3 hours), then 450 mg IV q8h (infused over 3 hours) | No data |
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.
Restricted to ID or Antimicrobial Stewardship