Ceftolozane/tazobactam (Zerbaxa)

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl >50 mL/min 30-50 mL/min 15-29 mL/min
Complicated urinary tract infection 1.5 g IV q8h 750 mg IV q8h 375 mg IV q8h
Pneumonia, severe infections 3 g IV q8h 1.5 g IV q8h 750 mg IV q8h

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis


Intermittent Hemodialysis

Continuous Hemodialysis
Complicated urinary tract infection 750 mg IV x1, then 150 mg IV q8h No data
Pneumonia, severe infections 2.25 g IV x1, then 450 mg IV q8h No data

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.

Restricted to ID or Antimicrobial Stewardship