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Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | CrCl > 50 mL/min | 31 - 50 mL/min | 16 - 30 mL/min | 6 - 15 mL/min | < 5 mL/min |
|---|---|---|---|---|---|
| All Indications | 2.5 g IV q8h infused over 3 hours | 1.25 g IV q8h infused over 3 hours | 0.94 g IV q12h infused over 3 hours | 0.94 g IV q24h infused over 3 hours | 0.94 g IV q48h infused over 3 hours |
Dosage recommendations are expressed as total grams of the ceftazidime/avibactam combination.
If aztreonam used in combination with ceftazidime-avibactam and dosing intervals are the same, simultaneous administration is preferred.
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
|
Indication |
Intermittent Hemodialysis |
Continuous Hemodialysis |
|---|---|---|
| All Indications |
0.94 g IV x1 now then qPM infused over 3 hours Alternative for minimal residual kidney function & less severe infections: 0.94 g IV q48h in evening infused over 3 hours |
2.5 g IV q8h infused over 3 hours |
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.
Restricted to ID or Antimicrobial Stewardship