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Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | CrCl > 50 mL/min | 31 - 50 mL/min | 16 - 30 mL/min | 6 - 15 mL/min | < 5 mL/min |
|---|---|---|---|---|---|
| All Indications | 2.5 g IV q8h | 1.25 g IV q8h | 0.94 g IV q12h | 0.94 g IV q24h | 0.94 g IV q48h |
Dosage recommendations are expressed as total grams of the ceftazidime/avibactam combination.
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
|
Indication |
Intermittent Hemodialysis |
Continuous Hemodialysis |
|---|---|---|
| All Indications |
0.94 g IV x1 now then qPM Alternative for minimal residual kidney function & less severe infections: 0.94 g IV q48h in evening |
2.5 g IV q8h |
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.
Restricted to ID or Antimicrobial Stewardship