Ceftazidime/avibactam (Avycaz)

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication CrCl > 50 mL/min 31 - 50 mL/min 16 - 30 mL/min 6 - 15 mL/min < 5 mL/min
All Indications 2.5 g IV q8h 1.25 g IV q8h 0.94 g IV q12h 0.94 g IV q24h 0.94 g IV q48h

 Dosage recommendations are expressed as total grams of the ceftazidime/avibactam combination.

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis


Intermittent Hemodialysis

Continuous Hemodialysis
All Indications

0.94 g IV x1 now then qPM

Alternative for minimal residual kidney function & less severe infections: 0.94 g IV q48h in evening

2.5 g IV q8h

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.

All use requires authorization from the Antimicrobial Stewardship Program or consulting ID fellow