UCSF Benioff Children's Hospital Antimicrobial Susceptibility Gram-positives Inpatients/ED

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N/A - testing NOT APPLICABLE to organism. PCN - penicillin, NAF - nafcillin, CLIN - clindamycin, CIP - ciprofloxacin, DOX - doxycycline, T/S - trimethoprim/sulfamethoxazole, VANC - vancomycin

Values are % of isolates testing susceptible to listed antibiotic. Unless indicated, results are for all inpatient/ED locations and culture sites. 

For all organisms, the number of isolates and susceptibilities are based on combined data from 2015-2017. Isolate numbers and 95% confidence intervals are provided to guage precision of susceptibility estimates. 

Organism

Total

Isolates

NAF

%S

(95% CI)

CLIN

%S 

(95% CI)

CIP

%S

(95% CI)

DOX

%S

(95% CI)

T/S

%S

(95% CI)

VANC

%S

Staphylococcus aureus

392

80

(75, 83)

83

(79,87)

82

(77,85)

94

(91,96)

97

(95,98)

100

MRSA

80

N/A

78

(67,86)

39

(28,50)

94

(86,98)

96

(89,99)

100

MSSA

312

100

84

(80,88)

93

(89,95)

94

(91,97)

97

(95,99)

100

Staphylococcus epidermidis

115

28

(20,37)

60

(50,69)

63

(54,72)

87

(79,93)

56

(46,65)

100

 

Click here for Enterococcus spp. susceptibilities

Streptococcus pneumoniae

Between inpatient and outpatient settings there were only 17 isolates of Streptococcus pneumoniae with full susceptibility testing performed. 15 of 17 (88%; 95% CI 64,99) were susceptible to penicillin based on the non-meningitis breakpoint (MIC<=2). 

For empiric treatment of meningitis in the non-neonate, pending susceptibilities, vancomycin should be added to the regimen since failures (due to highly resistant isolates) have been reported with ALL third generation cephalosporins.