UCSF Benioff Children's Hospital Antimicrobial Susceptibility: E. coli Susceptibility Among Outpatients

The predominant organism causing urinary tract infections among outpatients is E. coli.  Sensitivities for E. coli isolates submitted for outpatients in 2020-2022 are summarized below. Isolate numbers and 95% confidence intervals are provided to gauge precision of susceptibility estimate. 

Drug Percent susceptible (of 112 isolates; 95% CI)
Cephalexin* Pending update**
TMP/SMX 83 (75,89)
Ciprofloxacin 87 (80,92)
Nitrofurantoin** 100 (97,100)

* Cephalexin susceptibility determined using breakpoint = 16 for uncomplicated UTI, based on cefazolin MIC

** Previous susceptibility 2019-2021 based on 106 isolates = 97% (91, 99). Cephalexin susceptibility report is not yet updated for 2022 due to need for further report validation.

*** Nitrofurantoin should only be used for cystitis, in patients with CrCl>60ml/min