UCSF Benioff Children's Hospital Antimicrobial Susceptibility: E. coli Susceptibility Among Outpatients

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The predominant organism causing urinary tract infections among outpatients is E. coli.  Sensitivities for E. coli isolates submitted for outpatients in 2015-2017 are summarized below.  Note that these may underestimate the likelihood of resistance among patients with extensive prior antimicrobial treatment.

Drug Percent susceptible (of 115 isolates; 95% CI)
Cephalexin* 97 (91, 99)
TMP/SMX 72 (65,78)
Ciprofloxacin 91 (86,94)
Nitrofurantoin** 99 (95,100)

* Cephalexin susceptibility determined using breakpoint = 16 for uncomplicated UTI, based on cefazolin MIC

** Nitrofurantoin should only be used for cystitis, in patients with CrCl>60ml/min