Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | CrCl >10 mL/min | CrCl < 10 mL/min |
|---|---|---|
| Standard Dose | 500 mg IV/PO Q8h | 500 mg IV/PO Q12h |
| Bacterial vaginosis | 500 mg IV/PO Q12h | 500 mg IV/PO Q12h |
|
Intra-abdominal infections (excluding C. difficile) |
500 mg IV/PO Q12h | 500 mg IV/PO Q12h |
| Vaginal Trichomoniasis | 500 mg IV/PO Q12h | 500 mg IV/PO Q12h |
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
|
Indication |
Intermittent Hemodialysis |
Continuous Hemodialysis |
|---|---|---|
| Standard Dose | 500 mg IV/PO Q8h | 500 mg IV/PO Q8h |
| Bacterial vaginosis | 500 mg IV/PO Q12h | 500 mg IV/PO Q12h |
| Intra-abdominal infections (excluding C. difficile) | 500 mg IV/PO Q12h | 500 mg IV/PO Q12h |
| Vaginal Trichomoniasis | 500 mg IV/PO Q12h | 500 mg IV/PO Q12h |
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.