- Simplified inclusion/exclusion criteria - Added flow chart to guide antibiotic selection - Updated dosing table and recommended antibiotic options to reflect newer data - Added section on duration of therapy in patients with immunocompromise to support decision-making in these situations - Enhanced section on select resistance mechanisms for clarity - Added section on commonly asked questions for clarity and completeness - Removed tables on bioavailability, inferred susceptibility, and other considerations to focus guideline recommendations and streamline decision making