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Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | CrCl > 60 mL/min | 40 - 59 mL/min | 25 - 39 mL/min | 10 - 24 mL/min |
|---|---|---|---|---|
| CMV Treatment | 900 mg PO q12h | 450 mg PO q12h | 450 mg PO q24h | 450 mg PO every other day |
| CMV Prophylaxis | 900 mg PO q24h | 450 mg PO q24h | 450 mg PO q48h | 450 mg PO twice weekly |
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
|
Indication |
Intermittent Hemodialysis |
Continuous Hemodialysis |
|---|---|---|
| CMV Treatment | 450 mg PO x1 now and post-HD | 450 mg PO q24h |
| CMV Prophylaxis | 450 mg PO twice weekly | 450 mg PO q48h |
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.
*IV ganciclovir prefferred for initiation of therapy for unstable renal function or in dialysis
Take with food