Piperacillin/tazobactam SHORT Infusion (SI) (Zosyn)

Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication  > 50 mL/min 10 – 50 mL/min < 10 mL/min
NOTE: (UCSF Only) Use SHORT INFUSION only for patients excluded from EXTENDED INFUSION dosing

Non-Pseudomonas infections

3.375 g IV q6h

3.375 g IV q8h

2.25 g IV q8h
Documented/Suspected Pseudomonas aeruginosa infection

CrCl > 20 mL/min:

4.5 g IV q6h

CrCl < 20 mL/min:

3.375 g IV q8h


Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis


Intermittent Hemodialysis

Continuous Hemodialysis
All Indications 2.25 g IV q8h UCSF: Use EXTENDED infusion: Loading dose of 4.5 g IV over 30 minutes x1, then 4.5 g IV over 4h every 8h (starting 4 hr after loading dose)

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.

ONLY for patients excluded from EI dosing at UCSF. Exclusion criteria for EI: Resistant or intermediate organism, cystic fibrosis, periprocedural areas, insufficient IV access