Dosing: Adult Antimicrobial Dosing, Non-dialysis

Indication > 50mL/min 26 - 50 mL/min 10 - 25 mL/min < 10mL/min
Standard Dosing 1 g IV q8h 1 g IV q12h 500 mg IV q12h 500 mg IV q24h
Meningitis, Cystic Fibrosis 2 g IV q8h 2 g IV q12h 1 g IV Q12h 1 g IV q24h

Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis


Intermittent Hemodialysis

Continuous Hemodialysis (CVVHD)
Standard Dosing 500 mg IV x1 now, then qPM 1 g IV q8h
Meningitis, Cystic Fibrosis 1000 mg IV x1 now, then qPM 1 g IV q8h & consult ID pharmacy

Dialysis Notes

Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min.  For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.