Dosing Weights
Dosing: Adult Antimicrobial Dosing, Non-dialysis
| Indication | CrCl > 30 mL/min | 15-30 mL/min | < 15 mL/min |
|---|---|---|---|
| Systemic GNR infections, Nocardia | 10 mg TMP/kg/day divided Q6-12h | 5 mg TMP/kg/day divided Q6-12h | 2.5 mg TMP/kg Q24h |
| Pnemocytisis pneumonia , CNS infections | 15 - 20 mg TMP/kg/day divided Q6 – 12h | 7.5-10 mg TMP/kg/day divided Q12-24h | 4 - 5 mg TMP/kg Q24h |
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
|
Indication |
Intermittent Hemodialysis |
Continuous Hemodialysis |
|---|---|---|
| Systemic GNR Infections | 2.5 - 5 mg TMP/kg x1 now and qPM | 5 - 7.5 mg TMP/kg/day divided q12h |
| Pneumocystis pneumonia | 5 - 10 mg TMP/kg IV x1 now and qPM | 10 - 15 mg TMP/kg/day IV divided q6h - q12h |
Dialysis Notes
Intermittent HD assumes high-flux hemodialysis. CRRT assumes CVVHD with ultrafiltration rate 2L/h and residual native GFR < 10 mL/min. For detailed view of dialysis dosing and evidence, see Dosing in Hemodialysis document.
Single-strength (SS) tablet contains 80 mg trimethoprim (TMP)
Double-strength (DS) tablet contains 160 mg trimethoprim (TMP)
*May consider Total BW for serious infections