Maximum Dosing for Amoxicillin and Amoxicillin-Clavulanate

Although the absolute maximum Amoxicillin dose is 4000mg/day, we recommend the following for usual maximum dosing when targeting a high dose (80-90mg/kg/day):

  • Amoxicillin suspension - usual maximum 2000mg/day = 1000mg/dose BID
  • Amoxicillin tablet - usual maximum 875mg/dose or 1000mg/dose (2 of the 500mg tablets)
  • Amoxicillin-clavulanate (Augmentin) suspension - usual maximum 2000mg/day based on amoxicillin component
    • If patient weight < 40kg, use Augmentin-ES 600mg/5ml formulation 
    • If patient weight >= 40kg, use regular Augmentin 400mg/ml formulation
  • Amoxicillin-clavulanate (Augmentin) tablet
    • Usual maximum 875mg amoxicillin/dose BID
    • For acute bacterial sinusitis with high-risk features such as systemic illness, fever 39C or higher, or immunocompromised host, use maximum dose of 2000mg amoxicillin/dose BID (2 of the 1000mg XR tablets)