Drug

CrCl > 30 mL/min

CrCl 15 – 29 mL/min

CrCl <15 mL/min

Dialysis (HD)

Cephalexin (Keflex)

500 mg PO q6h

or 1 gm PO TID

500 mg PO q12h

500 mg PO q24h

500 mg PO q24h

(after HD on dialysis days)

Clindamycin

Weight-Based (using total body weight):

60 – 90kg: 300mg PO q8h

90 – 120kg: 450mg PO q8h

120 – 180kg: 450mg PO q6h

>180 kg: 600mg PO q6h

TMP/SMX (Bactrim or Septra)

*Weight based dosing (using total body weight) 

(Ideally ≥5mg/kg/day)

60-90kg: 1 DS tablet PO q8h

90-120kg: 2 DS tablets PO q12h

120-180kg: 2 DS tablets PO q8h

>180kg: 2 DS tablets PO q6h

(Ideally ≥2.5mg/kg/day)

60-90kg: ½ DS tablet PO q8h

90-120kg: 1 DS tablets PO q12h

120-180kg: 1 DS tablets PO q8h

>180: 1 DS tablets PO q6h

Not Recommended

Doxycycline

100mg PO q12h

Amoxicillin/Clavulanic Acid (Augmentin)

875 mg PO q12h

10-29 mL/min

500 mg PO q12h

<10 mL/min

500 mg PO q24h

500 mg PO q24h

(after HD on dialysis days)