Pertussis | Infectious Diseases Management Program at UCSF

Patient Population:

Pediatric

Condition	Major Pathogens	First Choice Therapy	Alternative Therapy	Comments
Pertussis	Bordetella pertussis	Age < 6 months: Azithromycin  10 mg/kg/dose enterally or IV daily x 5 days ------------------------ Age >= 6 months: Azithromycin  10 mg/kg/dose (max 500 mg/dose) once enterally or IV on day 1 , then 5 mg/kg/dose (max 250 mg/dose) enterally or IV daily on days 2-5	Refer to CDC guidelines below	Provided regimens can also be used for post-exposure prophylaxis Refer to CDC guidelines on post-exposure prophylaxis Enteral therapy is preferred once it can be tolerated

Condition

Major Pathogens

First Choice Therapy

Alternative Therapy

Comments

Pertussis

Bordetella pertussis

Age < 6 months:

Azithromycin 
10 mg/kg/dose enterally or IV daily x 5 days

------------------------

Age >= 6 months:

Azithromycin 
10 mg/kg/dose (max 500 mg/dose) once enterally or IV on day 1 , then 5 mg/kg/dose (max 250 mg/dose) enterally or IV daily on days 2-5 

Refer to CDC guidelines below

Provided regimens can also be used for post-exposure prophylaxis

Enteral therapy is preferred once it can be tolerated

Reference: