| Condition | Major Pathogens | First-choice Therapy | Alternative Therapy | Comments |
|---|---|---|---|---|
|
Syphilis (congenital) Refer to CDPH algorithm for guidance on interpretation of infant risk and recommended evaluation |
Treponema pallidum |
Full treatment course (as indicated per algorithm): Preterm infant (<=36 weeks GA): Refer to neonatal dosing guidelines for penicillin interval adjustments ------------------------- Age <=7d: ------------------------- Age 8 days to <1 month: ------------------------- Age >=1 month: ------------------------- Single dose - only use in selected infants as indicated per algorithm: Benzathine penicillin 50,000 units/kg IM x 1 dose |
Consider ID consult Duration (IV): 10 days Penicillin treatment should be continued without interruption; if > 1 day of treatment is missed, the entire course should be resumed and continued for the full duration from time of re-initiation |
References:
American Academy of Pediatrics. In: Kimberlin DW, Barnett ED, Lynfield R, Sawyer MH, eds. Red Book: 2021 Report of the Committee on Infectious Diseases. 32nd ed. Elk Grove Village, IL: American Academy of Pediatrics; 2021.
California Department of Public Health: Congenital Syphilis Resources for Providers